Theoretical-methodological bases of researching the notion of “non-monetary inequality”

Objective: to study the conceptual characteristics of non-monetary inequality in the modern Russian and foreign literature.Methods: analysis and synthesis, comparative analysis, generalization.Results: the article presents the results of a review of the modern Russian and foreign works on the study of non-monetary aspects of inequality. The paper substantiates the limitations of monetary and metric approaches in assessing the society stratification. The main approaches to the study of non-monetary differentiation are identified: deprivation, discrimination, self-identification and resource approaches. The author’s interpretation of the “non-monetary inequality” category is presented. It is shown that non-monetary inequality is a societal phenomenon. The conclusion is made that it is necessary to supplement income differentiation with evaluation of the characteristics of non-monetary inequality. In the future, it would be possible to develop and test a methodology for assessing non-monetary inequality of a region’s population.Scientific novelty: the author’s interpretation of non-monetary inequality is presented; the features of this socio-economic category are defined.Practical significance: the main provisions of the article can be used for further theoretical and methodological research and practical recommendations for reducing non-monetary differentiation

The role of arginine and endothelial nitric oxide synthase in the pathogenesis of Covid-19 complicated by metabolic syndrome

This literature review presents the role of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO), as well as arginine, the enzyme substrate, in the disease of metabolic syndrome and COVID-19 (SARS-CoV-2 virus). Metabolic syndrome is a combination of obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension. It has been shown that in elderly people, patients with obesity, metabolic syndrome, type 2 diabetes mellitus (DM2), and patients with COVID-19, endothelial dysfunction (ED) and vascular endothelial activation are detected. ED is the main cause of a number of pathological conditions during the development of COVID-19 and earlier in patients with metabolic syndrome, while a sharp drop in the level of nitric oxide (NO) is detected due to a decrease in the expression and activity of eNO synthase and enzyme depletion, which leads to a violation of the integrity of bloodvessels, that is, to vasoconstrictive, inflammatory and thrombotic conditions, followed by ischemia of organs and edema of tissues. It should be noted that metabolic syndrome, DM2, hypertension and obesity, in particular, are age-related diseases, and it is known that blood glucose levels increase with age, which reduces the bioavailability of NO in endothelial cells. Defects in the metabolism of NO cause dysfunction in the pulmonary blood vessels, the level of NO decreases, which leads to impaired lung function and coagulopathy. The review presents possible mechanisms of these disorders associated with ED, the release of eNO synthase, changes in phosphorylation and regulation of enzyme activity, as well as insulin resistance. A modern view of the role of the polymorphism of the eNO synthase gene in the development of these pathologies is presented. To increase the level of endothelial NO, drugs are offered that regulate the bioavailability of NO. These include arginine, agonist NO – minoxidil, steroid hormones, statins, metformin. However, further research and clinical trials are needed to develop treatment strategies that increase NO levels in the endothelium

Neuronal nitric oxide synthases in the pathogenesis of metabolic syndrome

The study of the molecular mechanisms of metabolic syndrome (MS) and its complications are among the most acute problems of modern endocrinology. Functional changes in the expression, activity, and regulatory properties of neuronal NO synthase (nNOS), which catalyzes the formation of the most important secondary mediator, nitric oxide (NO), and its dependent NO/cGMP signaling pathways in the brain, myocardium, and skeletal muscles, play a key role among the molecular causes of MS. In the brain, nNOS is associated with NMDA receptors, the hyperactivation of which in MS leads to excessive stimulation of nNOS and hyperproduction of NO, which leads to NO-induced damage to neurons and disruption of the central regulation of physiological processes and neurodegeneration. In the myocardium with MS, there are changes in the expression and localization of nNOS, as well as its functional interaction with cytoskeletal proteins, which leads to disorders of myocardial contraction and hypertrophy. In skeletal muscles, nNOS controls their contraction, oxidative metabolism, is involved in the regulation of vascular relaxation, and also participates in the regulation of glucose transport. A decrease in the expression and activity of nNOS, as well as dysregulation of its activity in MS, cause disturbances of these processes and make a significant contribution to the development of insulin resistance and deterioration of glucose homeostasis. Thus, nNOS can be considered an important therapeutic target in the treatment of MS and other metabolic disorders, as well as to prevent their complications from the nervous and cardiovascular systems and the musculoskeletal system

Mechanism of dicarbonyl(2,4-pentanedionato)iridium(I) decomposition on iron surface and in gas phase: Complex experimental and theoretical study

The mechanism of thermal destruction of Ir(acac)(CO)2 as one of the most important MOCVD precursors for Ir coatings deposition was proposed on the footing of the in situ mass spectrometry analysis and quantum chemical modeling. Calculated structural parameters and vibrational spectra of Ir(acac)(CO)2 molecule were found to be in a fairly good agreement with the experimental data. Ir(acac)(CO)2 was found to unlikely decompose in the gaseous phase while its adsorption onto the iron surface leads to major structural distortions easing the bond cleavage, molecule decomposition with subsequent formation of iridium films

Hygienic assessment of working conditions of workers of the main professions of the thermal power plant

The purpose of the study is tostudy of working conditions of workers of the main professions of the CHP.Цель исследования – изучение условий труда рабочих основных профессий ТЭЦ

Probing a Complex of Cytochromecand Cardiolipin by Magnetic Circular Dichroism Spectroscopy: Implications for the Initial Events in Apoptosis

Oxidation of cardiolipin (CL) by its complex with cytochrome c (cyt c) plays a crucial role in triggering apoptosis. Through a combination of magnetic circular dichroism spectroscopy and potentiometric titrations, we show that both the ferric and ferrous forms of the heme group of a CL:cyt c complex exist as multiple conformers at a physiologically relevant pH of 7.4. For the ferric state, these conformers are His/Lys- and His/OH–-ligated. The ferrous state is predominantly high-spin and, most likely, His/–. Interconversion of the ferric and ferrous conformers is described by a single midpoint potential of -80 ± 9 mV vs SHE. These results suggest that CL oxidation in mitochondria could occur by the reaction of molecular oxygen with the ferrous CL:cyt c complex in addition to the well-described reaction of peroxides with the ferric form

АНАЛИЗ ЭКОНОМИЧЕСКИХ ПОКАЗАТЕЛЕЙ ЛИНИЙ ДЛЯ ПЕРЕРАБОТКИ МАСЛИЧНОГО ЛЬНА

Oil flax grows in many countries of the world. Fibre production on its basis can significantly increase the profitability of flax-growing farms. At the present stage, taking into account the real possibilities of the national economy, for its effective development  it is necessary to introduce advanced technologies. Cur-rently, processing enterprises may choose among different technological equipment lines to process oil flax into fibre and thus get additional profit. (Research purpose) The determination of a technologically and economical-ly effective line for oil flax processing. (Materials and methods) The main materials for calculation were represent-ed by the indicators of production capacity, the average annual value of fixed as-sets, the amount of money spent on salaries and wages, etc. The main research method is the balance method that allows making a plan in the form of a balance sheet that takes into account the sources of inputs and the requirements for these inputs. (Results and discussions) The authors have considered low-cost lines for oil flax processing into short fibre on the basis of disintegrators of various brands (from domestic and foreign producers), offered characteristics of the fibre obtained in the lines, and analyzed technical and economic indicators of various technologi-cal lines under different conditions, and the payback period of capital expenditures for different oil flax acreages. (Conclusions) The authors have determined that the most effective is the pro-cessing of oil flax from an area of at least 1000 hectares, with a throughput capaci-ty of raw materials of at least 1000 kg/h and a distance of the transportation of straw rolls to a processing site of 50 km. They have also obtained technological and economic data that can be used in the organization of oil flax processing into marketable fibre.Лен масличный произрастает во многих странах мира. Его использование для получения волокна может значительно повысить доходность льносеющего хозяйства. На современном этапе с учетом реальных возможностей отечественной экономики для эффективного развития льноводства необходимо внедрять прогрессивные технологии. В настоящее время у переработчиков есть выбор линии технологического оборудования переработки масличного льна в волокно для получения дополнительной  прибыли.  (Цель исследования) Определить технологически и экономически эффективную линию для переработки масличного льна. (Материалы и методы) Основные материалы для расчета – показатели производственной мощности, среднегодовой стоимости основных производственных фондов, объема денежных средств, направленных на оплату труда. Ведущий метод исследования – балансовый, позволяющий составить план, учитывающий источники ресурсов и потребность в них. (Результаты и обсуждения) Рассмотрели малозатратные  линии для переработки масличного льна в короткое волокно на основе дезинтеграторов различных марок (отечественного и иностранного производства). Сравнили характеристики волокна, получаемого на линиях. Проанализировали  технико-экономические показатели четырех технологических линий при разных условиях эксплуатации, сроки окупаемости капитальных затрат при различных площадях посева масличного льна. (Выводы) Установили, что наиболее эффективна переработка масличного льна с площади не менее 1000 гектаров,  при пропускной способности по сырью не менее 1000 килограмм  в час и при расстоянии перевозки рулонов к месту переработки – 50 километров. Получили технологические и экономические данные, которые можно использовать при организации переработки масличного льна в ликвидное волокно

Assessment of physical activity of students and adolescents

This is article presents an assessment of physical activity in schoolchildren of grades 5, 9 and 1st year students. The study showed that the level of physical activity decreases with age. For example, the frequency of walking every day decreased from 63.3% (5th and 9th grade) to 28.7% (students). Among the surveyed students, the share of those engaged in sports sections decreased from 90% (5th grade) and 77.8% (9th grade) to 25%. In comparison with school students, the frequency and duration of physical activity decreases. The results obtained indicate the need to expand the number of sports sections in higher educational institutions, the availability of sports facilities, as well as the rational distribution of free time from studyВ данной статье представлена оценка физической активности у школьников 5, 9 классов и студентов 1 курса. Исследование показало, что уровень физической активности с возрастом снижается. Например, частота прогулок каждый день уменьшилась с 63,3% (5 и 9 класс) до 28,7% (студенты). Среди опрошенных студентов снизилась доля занимающихся в спортивных секциях с 90% (5 класс) и 77,8% (9 класс) до 25%. У студентов по сравнению со школьниками уменьшается кратность и продолжительность занятий физическими нагрузками. Полученные результаты свидетельствуют о необходимости расширения числа спортивных секций в высших учебных заведениях, доступности спортивных объектов, а также рационального распределения свободного времени от учеб